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/ Lote, H.; Spiteri, I.; Ermini, L.; Vatsiou, A.; Roy, A.; Mc Donald, A.; Maka, N.; Balsitis, M.; Bose, N.; Simbolo, M.; Mafficini, A.; Lampis, A.; Hahne, J. Lote, H, Spiteri, I, Ermini, L, Vatsiou, A, Roy, A, Mc Donald, A, Maka, N, Balsitis, M, Bose, N, Simbolo, M, Mafficini, A, Lampis, A, Hahne, JC, Trevisani, F, Eltahir, Z, Mentrasti, G, Findlay, C, Kalkman, EAJ, Punta, M, Werner, B, Lise, SLote, H.
Neo-antigen analysis suggested minimal immunogenicity. Conclusion: Our data provide the first in vivo experimental evidence documenting the timing of metastatic progression in CRC and suggest that genomic instability might be more important than themetastatic potential of the primary cancer in dictating CRC fate.
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The primary tumour metastasized to the lung and the thyroid within a year from its onset.
The chest wall metastasis was caused by needle tract seeding, implying a known time of onset.
Patients and methods: Here, we describe the case of a colorectal cancer (CRC) patient presenting with synchronous lung metastasis and metachronous thyroid, chest wall and urinary tract metastases over the course of 5 years.
TY - JOURT1 - Carbon dating cancer T2 - Annals of Oncology AU - Lote, H.
KW - Cancer evolution KW - Metastatic colorectal carcinoma KW - Mutational analysis KW - Phylogenetic tree KW - Synchronous metastases KW - Whole genome sequencing UR -